Levels of evidence (sometimes called hierarchy of evidence) are assigned to studies based on the research design, quality of the study, and applicability to patient care. Higher levels of evidence have less risk of bias.
Levels of Evidence (Melnyk & Fineout-Overholt 2023)
Level of Evidence
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Description
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Level 1 |
Evidence from a systematic review or meta-analysis of all relevant RCTs (randomized controlled trials).
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Level 2
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Evidence from at least one well-designed RCT (e.g. large multi-site RCT).
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Level 3
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Evidence from a single well-designed controlled trials without randomization (aka quasi-experimental studies) OR a systematic review of a complete BOE (integrative review of higher and lower evidence) OR mixed methods intervention studies
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Level 4
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Evidence from well-designed case-control or cohort studies
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Level 5
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Evidence from systematic reviews of descriptive and qualitative studies (meta-synthesis)
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Level 6
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Evidence from a single descriptive or qualitative study, EBP, EBQI and QI projects
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Level 7
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Evidence from the opinion of authorities and/or reports of expert committees, reports from committees of experts and narrative and literature reviews
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*Adapted from: Melnyk, & Fineout-Overholt, E. (2023). Evidence-based practice in nursing & healthcare: A guide to best practice (Fifth edition.). Wolters Kluwer.